KAIST Develops High-Resolution Real-Time Imaging Technique for Living Organoids

2024-10-29

A research team led by Professor Yong-Keun Park in the Department of Physics at the Korea Advanced Institute of Science and Technology (KAIST), in collaboration with the Center for Genome Engineering at the Institute for Basic Science (IBS) and Tomocube, has developed a novel holographic tomography-based imaging technology.

Organoids, three-dimensional mini-organs that mimic the structure and function of human organs, are essential tools for disease research and drug development. Conventional imaging techniques require additional fluorescent staining and have limitations in long-term, high-resolution observation.

This joint research team has developed a technology that enables real-time, high-resolution observation without the need for staining. This holographic tomography technique allows for the real-time monitoring of dynamic changes over extended periods without damaging the cells. The technology has been successfully validated using organoids derived from the small intestine of laboratory mice.

This technology is expected to expand the application of organoids in various fields, including drug development, personalized medicine, and regenerative medicine. Furthermore, this technology will contribute to a more accurate representation of the in vivo environment of organoids and enable a deeper understanding of various cellular-level biological phenomena through precise 3D imaging.

Source: https://www.etnews.com/20241014000176